THE DNMT3A PWWP DOMAIN IS ESSENTIAL FOR THE NORMAL DNA METHYLATION LANDSCAPE IN MOUSE SOMATIC CELLS AND OOCYTES.

The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.

DNA methylation at CG sites is important for gene regulation and embryonic development.In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by Fresh And Raw Frozen a DNA methyltransferase DNMT3A.DNMT3A has a PWWP domain, which recognizes H3K36me2/3, and heterozygous mutations in thi

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On Obtaining Energy-Optimal Trajectories for Landing of UAVs

The optimization issues connected to CAL CITRATE a landing task of an unmanned aerial vehicle are discussed in the paper, based on a model of a mini-class drone.Three landing scenarios are considered, including minimum-time landing, landing with minimum energy consumption, and planned landing.With the use of classical dynamic programming techniques

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Baseline Optimization for Spatial-Temporal Coupling in Geosynchronous Differential Synthetic Aperture Radar Tomography

Differential synthetic aperture radar tomography (D-TomoSAR) uses multiple SAR acquisitions at different times to form an elevation-time 2-D synthetic aperture, enabling recovery of the target's 3-D structure and deformation velocity.However, the imaging performance of D-TomoSAR is influenced by the spatial-temporal baseline distribution, wh

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